Abstract
We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.
MeSH terms
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Amidohydrolases / antagonists & inhibitors*
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Amidohydrolases / chemistry*
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Animals
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Azetidines / chemical synthesis*
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Azetidines / chemistry*
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Azetidines / pharmacology
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Catalysis
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Chemistry, Pharmaceutical / methods
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Humans
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Mice
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Mice, Knockout
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Models, Chemical
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Piperidines / chemical synthesis*
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Piperidines / pharmacology
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Rats
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Receptor, Cannabinoid, CB1 / chemistry
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Stereoisomerism
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Urea / chemistry*
Substances
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Azetidines
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Enzyme Inhibitors
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Piperidines
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Receptor, Cannabinoid, CB1
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VER 156084
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azetidine
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Urea
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Amidohydrolases
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fatty-acid amide hydrolase